VERTIGOHEELâ Fact Sheet

• VERTIGOHEELÒ is officially classified as a homeopathic combination medication available by prescription only and is indicated for the treatment of vertigo, other related imbalance disorders, and related symptoms such as nausea. VERTIGOHEELÒ is also indicated for the prevention and treatment of motion sickness.

• VERTIGOHEELÒ is a formulation of the following botanical, zoological, and mineral substances:

1. Botanical:

   Conium maculatum (umbelliferae)
   Cocculus indicus (menispermaceae)

     2. Zoological:
        Ambra grisea (ambergris)

     3. Mineral:
         Petroleum (purified mineral oil)

• The exact mechanism of action of VERTIGOHEELÒ is not fully understood. However, studies suggest that VERTIGOHEELÒ is effective in treating vertigo and nausea due in part to its ability to stimulate the central nervous system. VERTIGOHEELÒ activates the vestibular regulatory systems located in the brainstem area, which may facilitate more accurate communication between the peripheral vestibular system and the brain.

• Adverse effects with VERTIGOHEELÒ are extremely rare; it exhibits no known adverse renal, hepatic, cardiovascular, gastrointestinal or central nervous system effects and is generally well tolerated, even during long term administration.

• VERTIGOHEELÒ is contraindicated in patients with known hypersensitivity to it or any of its ingredients. VERTIGOHEELÒ is not known to interact with other medications or laboratory tests.

• An extensive, randomized, double-blind, controlled clinical trial demonstrated that VERTIGOHEELÒ is as effective betahistine (SercÒ , Sanofi Winthrop) in reducing the frequency, duration, and intensity of vertigo attacks. Betahistine is a drug that is routinely prescribed for the treatment of vertigo in Europe and other regions of the world, especially vertigo associated with Meniere's disease.

• VERTIGOHEELÒ is available in bottles of 100 tablets, Oral Drops in 50 ml bottles, and Oral Liquid in Vials, 1.1 ml packs of 10. All of the VERTIGOHEELÒ ingredients are included in the Homeopathic Pharmacopeia of the United States (HPUS), and the drug is manufactured and marketed in the U.S. according to the Food and Drug Administration's Code of Federal Regulations (including Good Manufacturing Practices) and Compliance Policy Guides - Conditions Under Which Homeopathic Drugs May be Marked.

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